To develop a novel restraint garment for cerebrovascular interventional procedures and investigate its safety and efficacy in cerebrovascular interventional surgeries. Methods: A total of 140 patients with acute large-artery occlusive stroke undergoing mechanical thrombectomy were enrolled and divided into a trial group (n=69) and a control group (n=71). The control group utilized conventional restraint straps, while the trial group employed the novel restraint garment for cerebrovascular interventional procedures. Comparisons were made between the two groups regarding the time to first vascular recanalization, total surgical time, 30-day modified Rankin Scale (mRS) score, intraoperative limb dislodgement rate, average surgical cost per patient, and safety indicators. Results: Compared with the control group, the novel restraint garment significantly shortened the time to first vascular recanalization [(43.5±13.7) min v.s (50.7±15.7) min, P=0.039] and total surgical time [(81.1±15.6) min v.s (93.2±21.1) min, P=0.027]. The trial group also demonstrated a significantly lower rate of limb dislodgement (0% v.s 35.2% , P<0.001) and reduced average surgical cost per patient [(76 315±12 400) yuan v.s (81 462±14 142) yuan, P=0.040] compared with the control group. In terms of safety, the rate of skin redness at the restraint site in the trial group (8.7% v.s 42.3%, P<0.001) was significantly lower than that in the control group. Conclusion: The novel restraint garment for cerebrovascular interventional procedures exhibits good safety and effectively shortens surgical time, reduces the intraoperative limb dislodgement rate, and lowers the average surgical cost per patient.