To investigate the correlation between depressive state during the acute phase of ischemic stroke and cognitive/functional outcomes one year later. Methods: Clinical data were collected from patients with acute ischemic stroke (AIS) admitted to Wuhan Central Hospital and Tongji Hospital from June 2018 to June 2019. At discharge, the severity of post-stroke depressive state was assessed using the Center for Epidemiological Studies Depression Scale (CES-D). During a one-year follow-up, cognitive function was evaluated using the Mini-Mental State Examination (MMSE), and functional outcome was assessed using the modified Rankin Scale (mRS). Multivariate logistic regression analysis was performed to examine the correlation between post-stroke depressive state (PSDS) and functional prognosis one year after stroke. Results: A total of 219 AIS patients were included and divided into PSDS and non-PSDS groups based on the presence of depressive state during the acute stroke phase. Baseline data analysis revealed significant differences in BMI and stroke type between the PSDS and non-PSDS groups (P<0.05). Multivariate logistic regression analysis indicated that compared to the non-PSDS group, the PSDS group had a significantly lower proportion of patients with cognitive impairment one year after stroke (P<0.001), while no statistically significant difference was observed between the two groups in the proportion of patients with good mRS prognosis. Conclusion: Depressive state during the acute phase of ischemic stroke is significantly associated with an increased risk of cognitive impairment one year after stroke but is not correlated with favorable functional outcome.