Parkinson's disease (PD) is one of the most common neurodegenerative diseases. Quantitative Susceptibility Mapping (QSM), a non-invasive method that utilizes magnetic resonance data acquisition, makes it possible to quantify brain iron content. This helps to understand the role of iron deposition in the pathogenesis of PD and is expected to become a new type of biomarker for PD. This paper briefly describes the research progress of QSM based on the principle of intracranial iron deposition in the motor symptoms, non-motor symptoms, treatment, and differential diagnosis of PD, providing a reliable imaging basis for QSM in the early diagnosis of PD and diseases. It is of great significance for the assessment of the condition of PD patients and the search for new treatment methods, thus proposing a new approach to understanding the brain iron physiology under disease conditions.