Acute ischemic stroke (AIS) ranks as the leading cause of disability and mortality among Chinese residents, posing severe challenges to societal economic development and public health. Mechanical thrombectomy, as a rapidly evolving treatment method in recent years, has gained global recognition for its efficacy. This article summarizes three major aspects: recent research on select indications within mechanical thrombectomy, comparisons of effectiveness and safety between direct thrombectomy and bridging therapy, and failures in mechanical thrombectomy due to anatomical access challenges.