Alzheimer’s Disease (AD) is a neurodegenerative disorder of the central nervous system manifested by progressive cognitive decline and behavioral alterations. Research indicates that the overactivation of the complement system significantly contributes to the pathology of AD, and suppressing this overactivation offers novel clinical approaches for AD diagnosis and treatment. This paper will discuss the relationship and advancements in research between the complement system and AD progression, as well as outline the progress in complement-targeted treatments for AD.