Neurodegenerative diseases are a group of chronic progressive neurological diseases mainly characterized by neuronal degeneration and loss, including Alzheimer's disease, Parkinson's disease, Huntington's disease and multiple system atrophy. Although the pathogenesis and typical manifestations of these diseases are different, they all present dysfunction in circadian rhythm. Circadian rhythm is a 24-hour rhythm that exists in the organism and is involved in regulating the physiological processes of the organism. Disruption of circadian rhythm can lead to abnormal hormone secretion, accumulation of pathogenic proteins, and neurodegenerative changes, accelerating the disease progression. This paper discusses the correlation between circadian rhythm disorder and neurodegenerative diseases.