In addition to mental anxiety, patients with post-stroke affective disorder also have somatic anxiety, such as dizziness, instability, palpitations, urination and fecal disorders. As vestibular symptoms, lethargy, instability described by patients may share some common neurobiological basis and signaling pathway with anxiety and depression. Due to the similar clinical features and possible overlapping neurobiological basis of persistent postural-perceptual dizziness (PPPD), it is speculated that patients with post-stroke affective disorder may be at risk for PPPD conversion. Therefore, this article reviews the latest researches on post-stroke affective disorder and PPPD in recent years.