Epilepsy is a clinical syndrome caused by highly synchronous abnormal discharge of neurons in the brain, which is caused by a variety of reasons. With a prevalence of 0.8% to 1.2%, epilepsy represents one of the most frequent chronic neurological disorders. 30% to 40% of patients suffer from drug-resistant epilepsy (regular use of first-line antiepileptic drugs for 2 years still cannot adequately control seizures). Epilepsy surgery represents a valuable treatment option for 10% to 50% of these patients. Epilepsy surgery aims to control seizures by resection of the epileptogenic tissue while avoiding neuropsychological and functional disorders by sparing essential brain areas. In this paper, the preoperative evaluation, location of epileptogenic focus, choice of operative mode and prognosis of refractory epilepsy surgery are summarized.