Astrocytes are the most widely distributed cells in the central nervous system, which have the functions of neuronal transmission, nerve support, maintaining the stability of blood-brain barrier, regulating endolymphatic circulation and nerve inflammation. Recent studies have shown that circadian rhythms are involved in the regulation of these functions. Circadian rhythm disorder of astrocytes can lead to disturbance of endolymphatic circulation, abnormal accumulation of neurotransmitters and pro-inflammatory mediators, this in turn leads to impaired cognitive function and rhythm disorder.