To explore the correlation between disease uncertainty and decision conflict in family members of ICU patients in department of neurology. Methods: 156 family members of ICU patients in neurology department were investigated by Disease Uncertainty Scalend Family Decision Conflict Scale. Results: The scores of disease uncertainty and decision conflict were 89.17±17.13 and 31.60±6.17, respectively. There was a positive correlation between decision conflict and disease uncertainty (r=0.359, P<0.05). Conclusion: The family members of ICU patients in the department of neurology have decision conflict, and disease uncertainty with moderate levels. There was a positive correlation between decision conflict and disease uncertainty.