To evaluate efficacy of vestibular rehabilitation training combined with drug therapy in the treatment of persistent postural-perceptual dizziness (PPPD) by meta-analysis. Methods: A search strategy was established to search the Cochrane Library, Pubmed, Web of Science, VIP database (VIP), China Journal full-text database (CNKI), and Wanfang database (Wanfang) for clinical randomized controlled trials of vestibular rehabilitation training combined with drugs in the treatment of PPPD from up to March 2021. Two researchers independently screened the literature, extracted data, and evaluated the quality of the literature. Meta-analysis was carried out using Review Manager 5.3 software. Results: After final screening, 10 articles were obtained, all of which were randomized controlled trials, with a total of 904 patients with PPPD. Results of the meta-analysis showed that, compared with conventional drug therapy, vestibular rehabilitation training combined with drug therapy relieved symptoms of dizziness [MD=－7.19, 95%CI (－9.52, －4.86), P<0.01], anxiety [MD=－2.45, 95%CI (－4.39, －0.51), P<0.01], and depression [MD=－3.59, 95%CI (－6.10, －1.09), P<0.01] and increased the effective rate [OR=2.46, 95% CI (1.43, 4.21), P<0.01]. Conclusion: Vestibular rehabilitation training combined with drugs is effective in the treatment of PPPD. Compared with conventional drug therapy, vestibular rehabilitation training combined with drugs can better improve the subjective symptoms of dizziness and reduce the negative emotions of anxiety and depression.