To explore the effect of timing-it-right discharge preparation service on improving the care ability of the main caregivers of stroke patients, so as to reduce the recurrence of stroke. Methods: Using convenience sampling, 100 stroke patients and their 100 caregivers were collected. According to sequential order, they were divided into the control group and test group with 50 cases in each. The control group was given routine nursing care , while the test group was given routine nursing care and timing-it-right discharge preparation service. Patients in both groups were followed for 6 months after discharge. The family caregiver task inventory (FCTI) and Barthel index (BI) were used to assess and compare the two groups of caregivers and patients at admission, discharge, 3 months after discharge, and 6 months after discharge. Results: At the end of the 6-month follow up, 46 cases had been collected (4 cases lost) in the control group and 47 cases (3 cases lost) had been collected in the test group. At discharge, the FCTI total score in both groups showed a decrease compared to values at admission (P<0.05), and the test group showed a lower score than the control group (P<0.05). There was no significant difference between the two groups in patient BI score at discharge (P>0.05); at 3 and 6 months after discharge, the test group patients showed a higher BI score than the control group patients (P<0.05). When comparing within each group, both groups showed a significantly different BI score at 3 and 6 months after discharge compared to the same group at admission and discharge (P<0.05). Conclusion: Timing-it-right discharge preparation service can greatly improve the care ability of caregivers of stroke patients in a short time and can improve the self-care ability of discharged patients.