To explore effect of brain and heart health manager-led health management on self-management behavior and medication compliance of young and middle-aged patients with ischemic stroke. Methods: Young and middle-aged patients (n=112) with ischemic stroke were divided into the control group (55 cases) and intervention group (57 cases). The control group was given routine management and follow-up, and the intervention group was given brain and heart health manager-led health management. The effect of intervention was evaluated by the youth stroke patient self-management behavior scale and 8-item medication compliance scale before intervention and 3 months after intervention. Results: After intervention, the total score of self-management behavior and the scores of disease management, daily life management, diet self-management, rehabilitation exercise management, and resource utilization management in the intervention group were significantly higher than those in the control group (P<0.01). The compliance of the intervention group was also higher than that of the control group (P<0.01). Conclusion: Brain and heart health manager-led health management improves the self-management behavior of young and middle-aged patients with ischemic stroke, and also improves their medication compliance.