To analyze the relevant risk factors of hypoalbuminemia (HA) in patients with spinal cord injury (SCI). Methods: We performed a retrospective analysis of 112 patients with SCI admitted to the Department of Rehabilitation Medicine in our hospital from June 2019 to October 2020 and perfected serum total protein and albumin examinations upon admission. According to examination results, the patients were divided into the HA group and non-HA group, and the gender, age, course of disease, segment of injury (tetraplegia and paraplegia), degree of injury (complete spinal cord injury and incomplete spinal cord injury), and presence or absence of complications (pulmonary infection and deep vein thrombosis of the lower extremities) were recorded. Collection of clinical data such as blood glucose, creatinine, serum magnesium concentration, and lymphocyte count was completed early morning on the day following admission. First, single-factor analysis was used, and multi-factor logistic regression analysis was performed according to the analysis results to screen for relevant risk factors of HA in patients with SCI. Results: Univariate analysis showed that age, course of disease, quadriplegia, complete spinal cord injury, lung infection, deep vein thrombosis of the lower limbs, blood sugar, and lymphocyte count may be related to the occurrence of HA in SCI patients (P<0.05). Regression analysis showed that lung infection and deep vein thrombosis of the lower extremities were risk factors for the occurrence of HA in SCI patients. Con? clusion: Pulmonary infection and deep vein thrombosis of lower limbs may be the risk factors of HA in patients with SCI.