To investigate the predicting factors associated with the 6-month prognosis of spontaneous supratentorial intracerebral hemorrhage (ICH) after minimally invasive intracranial hematoma suction drainage surgery (MIS). Methods: Patients with ICH who underwent MIS in our hospital from July 2012 to December 2013 were retrospectively collected. Patients’clinical data, imaging data, and 6-month modified Rankin Scale (mRS) scores were recorded. An mRS score of 0 to 3 was defined as good prognosis, and a score of 4 to 5 was defined as poor prognosis. Multivariate logistic regression analysis was used to evaluate the predicting factors associated with 6-month prognosis after surgery. Results: A total of 75 patients were enrolled in this study; based on the mRS scores at the 6-month follow-up, 47 patients were placed in the good prognosis group and 28 in the poor prognosis group. Compared with those in the good prognosis group, patients in the poor prognosis group tended to have a lower GCS score and a higher NIHSS score at admission and more likely presented with the“swirl sign”and“island sign”on baseline CT images (all P<0.05). Multivariate logistic regression analysis showed that admission GCS score and being baseline CT swirl sign-positive were independent predicting factors of 6-month prognosis after MIS. Conclusion: Admission GCS score and being baseline CT swirl sign-positive are independent predictors for 6-month prognosis of ICH patients after MIS.