To explore the correlation of the SREBF1 gene SNP rs11868035 with Parkinson’s disease (PD) in the Han population of central China. Methods: We included 471 patients with idiopathic PD and 536 healthy controls, all of Han ethnicity, in this study, and compared the rs11868035 allele and genotype frequency differences between the two groups. A meta-analysis was conducted to further evaluate the correlation between rs11868035 and the incidence of PD in the Chinese population. Results: There were 3 genotypes (AA/AG/GG) of SNP rs11868035. There was no significant difference in allele frequency nor genotype between the PD group and control group (P>0.05). The meta-analysis showed that there might be no significant correlation between this site and PD incidence in the Chinese population. Conclusion: The SREBF1 gene SNP rs11868035 might not be correlated with the incidence of PD in the Han population of central China.