At the end of 2019, the new coronavirus pneumonia (corona virus disease 2019, COVID-19) outbreaked in Wuhan, Hubei. The number of infections increased sharply in a short period of time, and it spread rapidly throughout the country. After more than two-month full-scale anti-epidemic work, the epidemic defense of COVID-19 in Wuhan has achieved phased victory. We retrospectively analyzed the epidemic prevention activities and summarized the shortcomings in the early stage of epidemic prevention work in this article. The role of intelligent medicine application in early warning, response activities and hospital operating in major new infectious diseases outbreak were explored.