To explore the predictive value of the THRIVE Scale, mSOAR Scale and Simple Scale sores for 1-year adverse prognosis of patients with acute ischemic stroke (AIS). Methods: A total of 772 patients with AIS were enrolled. The clinical baseline data were collected and compared. All the patients were scored with THRIVE Scale, mSOAR Scale and Simple Scale, and were followed up for 1 year. Death or Modified Rankin score (mRS) ≥3 points at 1-year were regarded as a poor prognosis. The AUC value of area under the receiver operating characteristic curve (ROC) was used to compare the predictive values of the three scales. Results: According to the follow-up results, 576 cases (74.6% ) were included in good prognosis group and 196 cases (25.4% ) were included in poor prognosis group, of which 68 cases (34.7% ) died. The AUC values of THRIVE, mSOAR and Simple Scale for 1-year predictive adverse prognosis of AIS patients were 0.777 [95% CI, (0.738, 0.815)], 0.820 [95% CI, (0.706, 0.770)] and 0.854 [95% CI, (0.827, 0.878)] (all P<0.001). And the AUC values of the THRIVE and mSOAR scales were lower than that of Simple Scale (P<0.05). The AUC values of THRIVE, mSOAR and Simple Scale for death were 0.775 [95% CI, (0.721, 0.828)], 0.748 [95% CI, (0.716, 0.778)] and 0.807 [95% CI, (0.778, 0.835)] (all P<0.05). And the AUC value of mSOAR scale was lower than that of Simple Scale (P<0.05). Conclusion: THRIVE, mSOAR and Simple Scale have good predictive power for 1-year poor prognosis of AIS patients and the Simple Scale has a better predictive ability.