To investigate the clinical characteristics of acute panautonomic neuropathy (APN), which may be helpful for its early diagnosis and treatment. Methods：In this paper, 2 cases of APN from our hospital were reported and the relevant literature was reviewed. Results：The 2 APN patients were both male and middle-aged. Both patients showed acute or subacute onset with apparent dysfunction of the autonomic nervous system. Both cases presented normal cerebrospinal fluid and nerve conduction velocity. Early treatment with corticosteroid and immunoglobulins resulted in improved prognosis in the patients. Patient 1 was followed for 8 years and showed a lingering reduction in gastrointestinal function that required the use of parenteral nutrition for management. Patient 2 was followed for 3 years and showed residual mild orthostatic hypotension marked by occasional dizziness after standing; the patient was able to walk slowly and was capable of self-care. We collected the data of 54 cases of APN from MEDLINE. Most of these patients (67%) presented with orthostatic hypotension. Early intervention with corticosteroid and immunoglobulins resulted in a good prognosis for most patients. Conclusion：APN presents with widespread dysautonomia, especially orthostatic hypotension. Auxiliary examinations show no outstanding feature. Corticosteroid or immunoglobulins therapy are effective and result in a good prognosis. Patients may develop sequelae of varying severity.