To investigate the clinical characteristics of Parkinson's disease (PD) with anxiety and explore its risk factors. Methods: A cross-sectional study of PD patients was carried out in the outpatient department of our hospital and Beijing Tiantan Hospital. The clinical characteristics such as age of onset, disease duration, initial symptoms, modified H-Y stages, MDS-UPDRS-Ⅲ, combination with restless legs syndrome (RLS), and Becker anxiety scale scores were collected. The incidence and influencing factors of anxiety in PD were analyzed by multivariate logistic method. Results: A total of 263 PD patients were included; 65 patients (24.7% ) had anxiety, and 36 of these patients were female. Longer course of disease, higher H-Y stages and MDS-UPDRS- Ⅲ scores, and combination with RLS were positively related with anxiety (P?0.05), but there was no significant correlation between anxiety and the age of onset, education level, or initial symptoms (P ? 0.05). Conclusion: Being female, longer duration of disease, more severe motor function, and combination with RLS are risk factors for PD with anxiety.