To explore the clinical features, imaging manifestation, auxiliary examination, and treatment of transient global amnesia and gain deeper insight about this condition. Methods: The clinical data of 15 patients with transient global amnesia were collected and analyzed and discussed retrospectively. Results: Among the 15 patients, 67% were female, and the age range was 56~85 years with an average age of 67.1 years; 3 patients experienced simultaneous anxiety and depression. All 15 patients complained mainly of sudden memory loss, and this was accompanied by dizziness, headache, and other symptoms; 3 patients had emotional triggers before the onset of disease; 4 patients were found to have concurrent arrhythmias, and no abnormal spikes were found in the EEG. CTA of 5 patients indicated variation or narrowing of the posterior cerebral artery. No abnormal signal of DWI was detected by MRI in all patients. Antiplatelets and circulation enhancers were given to all patients, and 2 patients relapsed. Conclusion: Transient global amnesia presents mainly as the inhibition of new memory formation; it is a benign condition. Vascular factors, hypo-perfusion, and emotional stress are all involved in its pathogenesis.