To investigate the predictive value of SOAR and ASTRAL scores for one-year poor prognosis in patients with acute ischemic stroke (AIS). Methods: A total of 807 AIS patients were enrolled. Clinical baseline data were collected and scored with SOAR and ASTRAL scores. A prospective cohort follow-up study was performed for 1 year. The patient had a death or functional disability at 1 year [modified Rankin score (mRS) ≥3 points] as an adverse outcome event. The area under the receiver operating characteristic curve (AUC) was used to compare the predicted values of the two scales. Results: A total of 772 AIS patients' data were collected in the study. There were 196 (25.4% ) adverse outcomes at 1 year follow-up, including 68 deaths (8.8%). The AUR values for the 1-year adverse outcome of the AIS patients predicted by the SOAR and ASTRAL scales were 0.739, 0.860, respectively (both P＜0.001). Further comparisons were made between the two scales, the difference was statistically significant (P＜0.001). The 1 year mortality outcome of AIS patients was further analyzed by two scales. The AUC values were 0.755, 0.809 (both P＜0.001). Further comparison between the two groups was statistically significant (P＜0.001). Conclusion: The SOAR and ASTRAL scales can predict the 1-year adverse prognosis of AIS population. The ASTRAL scale is superior to SOAR scale in predicting 1-year adverse outcomes and death events in patients with AIS.