To summarize our experience with bone flap craniotomy in 12 cases of depressed skull fracture in the superior sagittal sinus area. Methods: For this study, we recruited 12 patients who were diagnosed with depressed skull fractures in the superior sagittal sinus area. All patients were treated with bone flap craniotomy. During the treatment process, the bone flap with fracture fragments was completely dissociated from the brain and repaired; meanwhile, debridement was performed to remove fracture fragments in the brain and eliminate intracranial hematoma. The cracked endocranium and superior sagittal sinus were repaired, and the repaired bone flap was restored and fixed. Results: Cranial three-dimensional CT scans for all patients after operation showed that depressed fractures were anatomically restored. Post-operation wound infection did not occur, and prognosis was excellent. Conclusion: Bone flap craniotomy is an effective treatment for depressed skull fractures in the superior sagittal sinus area.