To analyze the therapeutic effect of hyperbaric oxygen, Edaravone combined with ganglioside in the treatment of postoperative patients with severe craniocerebral injury. Methods: Sixty-four patients with severe traumatic brain injury were randomly divided into control group and experimental group after surgery, with 32 cases each. All the cases were treated with hyperbaric oxygen combined with Edaravone, and those in the experimental group were given extra ganglioside. The efficacy, Glasgow coma scale (GCS), National Institutes of Health Stroke Scale (NIHSS) and mini-mental state examination(MMSE) scores were compared between the two groups. Results: The total effective rate of the experimental group was 96.88% , significantly higher than 87.5% of the control group (P<0.05). After 2 and 4 courses of treatment, the GCS and MMES scores of experimental group were significantly higher than those of the control group (P<0.05), and NIHSS score was significantly lower than those of the control group (P<0.05). Conclusion: It is an effective way to treat postoperative patients with severe craniocerebral injury with hyperbaric oxygen, Edaravone combined with ganglioside, which can promote the recovery of neurological function and consciousness of patients