To investigate the mental health status of outpatients in neurology department, and analyze its influencing factors. Methods: 3703 cases of outpatients in the department of neurology were recruited. Symptom Checklist-90(SCL-90) was used to investigate their mental health status. Clinic data were collected and analyzed. Results: 73.51% of the cases scored more than 160. The SCL-90 total score and other subscales’scores were higher than those of national norm (P<0.05). Multiple linear regression analysis showed that age, gender and marital status were the influence factors of mental health of outpatient in neurology department, but which explained only 3% of the overall impact factors. Conclusion: The mental health status of outpatients in neurology department is poor, and it is necessary to provide psychological counseling accordingly.