To report the clinical manifestations of a case of“Mirror”symmetric astrocytoma, and analyze its clinical, imaging and pathological features. Methods: One case of intracranial“Mirror” symmetric astrocytoma was reported, and the relevant literatures were reviewed and retrospectively analyzed. Results: The patient was a male, 53 years old, who was admitted to the hospital because of“a loss of paroxysmal consciousness with limbs twitching for half a day”. The head MRI plain scanning and enhanced scanning displayed that the right frontal lobe existed a softening lesion; the left frontal lobe saw a patchy long T1 long T2 signal, and T2 Flair showed a slightly higher signal and mild enhancement. Surgical treatment was performed, and the left frontal lobe lesion was resected. Pathological biopsy: Left frontal lobe lesion had locally more intensive cells, and it was diagnosed as astrocytoma (WHO II). Immunohistochemistry: GFAP(+), Vim(+ ), S-100(+ ), NF(+ ), NSE(+ ), Ki-67 (+2% ). After operation, the patient recovered well and continuous radiotherapy and chemotherapy were recommended. We collected data of 31 cases of non-synchronous multicentric glioma reported in the last 5 years. Limb twitching is the most presented initial symptom. The plaque-like mixed abnormal signal and enhancement in different parts of the head was observed in all patients by plain and enhanced cranial MRI. The pathological type was more common in astrocytoma. Conclusion: Non-synchronous multi-centered gliomas can be characterized by limb convulsions, headaches, and partial sensory disturbances. For patients with intracranial astrocytoma, active surgical treatment combined with radiotherapy, chemotherapy and gene and biological treatment are beneficial to the survival of patients.