To report the clinical efficacy of vagus nerve stimulation (VNS) in the treatment of 3 patients with refractory epilepsy. Methods: Of the 3 patients in this study, 2 were female and 1 was male. The average age was 21.6 years old, and the average length of disease history was 13.7 years. All patients underwent surgery on the left vagus nerve. Stimulation was implemented at 2 weeks after surgery, and parameters were adjusted to the optimal level. Clinical efficacy was followed up for 2 years. Results: None of the 3 patients had any complications related to surgery or material, and the complications related to stimulation were relieved or disappeared after symptomatic treatment. Two years after stimulation, the McHugh score was rated as grade I in 2 cases and grade II in 1 case. In addition, the 3 patients experienced improvement of depression and anxiety as well as increased simple intelligence score compared with before surgery. Conclusion: Vagus nerve stimulation for the treatment of intractable epilepsy is a relatively safe and effective procedure.