To explore the clinical and imaging features of 13 cases of neuro-Behcet’s disease (NBD). Methods: A retrospective study was performed on 13 patients diagnosed with NBD. The data and imaging features were analyzed. Results: The main symptoms experienced by NBD patients were headache (5 cases), hemiplegia (5 cases), dizziness (4 cases), visual disturbance (3 cases), and epileptic seizures (3 cases). Biochemical examination of blood showed that all patients had increased inflammatory indexes such as erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP). Cerebrospinal fluid (CSF) examination showed increased CSF pressure, white blood cells (WBCs) count, and protein level. Brain magnetic resonance imaging (MRI) scans revealed multiple patches giving high signals on T1-weighted images, T2-weighted images, fluid-attenuated inversion recovery (FLAIR) images, and diffusion-weighted images (DWI) in the bilateral frontal lobes, temporal lobes, basal ganglia, and corona radiata. Additionally, slightly enlarged ventricles, widened sulcus, and stenosis in the intracranial vessels were also observed. Conclusion: NBD should be considered if the patient’s clinical characteristics suggest Behcet’s disease and are accompanied by neurological damage. Blood tests, plain and contrast-enhanced brain MRI scans, CSF examination, and pin-prick tests are required to confirm the diagnosis.