The purpose of this study was to explore the clinical features and imaging features of patients with medial medullary infarction（MMI）. Methods: Clinical data from 7 patients diagnosed with MMI was collected; clinical and radiological features were retrospectively analyzed, and related literature was reviewed. Results: The average age of onset in 7 patients was (59±0.7）years, and the ratio of males to females was 5∶2. The average onset period was (5.6±0.5）days. All patients presented cases of acute disease. The main clinical manifestations were dizziness, unclear speech, and weakness and numbness of limbs. There were 2 patients with narcolepsy and 1 patient with progressive aggravation. Diffusion-weighted magnetic resonance imaging（DWI）was performed on all patients to display high signal in the medial medulla. Two patients were diagnosed with bilateral intramedullary infarction, and 1 case showed a new occipital infarction. Magnetic resonance angiography （MRA） found localized stenosis or occlusion of vertebral artery in 5 patients. Conclusion: The clinical manifestation of MMI is complicated and varied and is especially rare in the bilateral medulla. Typical clinical manifestation is paralysis of the limbs with sudden onset of disease（both limbs display paralysis in bilateral MMI）, often accompanied by vagal nerve and hypoglossal nerve injury. Obtaining brain MRI and similar imaging results as soon as possible is helpful to improving the diagnosis and treatment of early diseases.