To explore the joint effect of laser irradiation in nasal cavity (LINC) and comprehensive speech therapy on patients with aphasia after cerebral infarction. Methods: 78 patients diagnosed with aphasia after cerebral infarction were collected and randomly divided into conventional therapy group (38 cases) and comprehensive therapy group (40 cases). Conventional therapy group accepted basic drug treatment and the Schuell Stimulation Method while comprehensive therapy group accepted LINC in addition to the methods used by conventional therapy. Therapy duration lasted 30 minutes per session, 1 session per day, 6 days per week, and 30 days per treatment course, for 1 treatment course. Western Aphasia Battery (WAB) and hemorheology were used to assess patient speech ability and curative effect before and after therapy. Results: After therapy, both groups showed significant increase in spontaneous speech, repetition, and naming, with comprehensive therapy group displaying a higher increase than conventional therapy group (P<0.05). Blood viscosity, fibrinogen content, and TCT were significantly lower post-therapy (P<0.05); additionally, comprehensive therapy group showed a significantly greater decrease than conventional therapy group (P<0.05). Conclusion: LINC combined with comprehensive speech therapy has a positive effect on recovery in patients with aphasia after cerebral infarction and furthermore has a beneficial influence on hemorheology