To investigate the prevalence and clinical characteristics of migraine in aerospace workers, explore the risk factors of migraine, and provide effective strategies for the prevention and treatment of migraine. Methods: A total of 1200 aerospace workers were investigated by stratified random cluster sampling and surveyed using a questionnaire of content including demographic data, headache diagnosis question, and sleep quality. Results: 136 cases met the diagnostic criteria of migraine, and the prevalence rate was 12.3%. Among these there were 52 cases (38.2%) of migraine with aura and 84 cases (61.8%) of migraine without aura. The average age was (33±10.72) years. There were 46 males (33.8%) and 90 females (66.2%). The majority of patients (92.6%) possessed a college education. There were 86 cases (63.2%) with unilateral pain and 62 cases (45.6%) with pulsatile pain. Duration of attack was 4-72 hours in 88 cases (64.7% ), and moderately severe cases numbered 112 (72.3%). 64 cases (47.1%) were accompanied by symptoms of phonophobia. 59 patients (43.3%) experienced nausea, and 86 patients (63.2%) had headaches which were aggravated by activity. Lack of sleep was the inducing factor in 99 cases (72.8%). Univariate analysis showed significant difference in the distribution of migraine among different sex, occupation type, and sleep quality groups (P<0.05). Multivariate Logistic regression showed that being female and poor sleep quality resulted in significantly increased risk for migraines (P<0.05). Conclusion: Migraine has high prevalence in aerospace workers; gender (female) and sleep disorders are among the main risk factors.