To observe the curative effect of acupuncture combined with drug therapy on facial numbness in patients after undergoing microvascular decompression for trigeminal neuralgia. Methods: A total of 72 patients with facial numbness after microvascular decompression surgery were randomly divided into the drug group and the combined group with 36 patients per group. The drug group received comprehensive drug therapy including the use of neurotrophic substances and vasodilators. The combined therapy group was given acupuncture treatment in addition to the interventions for the drug group. Prior to treatment and after one treatment cycle, trigeminal nerve function in both groups was assessed by the Barrow Neurological Institute (BNI) facial numbness score; in addition, quality of life was evaluated by SF-36 scores. Results: The treatment period of the combined group was shorter than that of the drug group (P<0.05). Before treatment, there was no significant difference between the BNI and SF-36 scores of the combined group and drug group (P>0.05). After treatment, both groups showed lower BNI scores and higher SF-36 scores compared to those before treatment (P< 0.05), and the combined group showed lower BNI scores and higher SF-36 scores than the drug group (P<0.05). Conclusion: Acupuncture combined with drugs can effectively promote the rehabilitation of trigeminal nerve function, improve the quality of life, and shorten the treatment period of patients with facial numbness after microvascular decompression surgery for trigeminal neuralgia.