To explore the changes in weight, fasting blood glucose (FBG), serum uric acid (UA), and lipid metabolism among adolescent schizophrenia patients of different sexes after 4-week treatment with atypical antipsychotic agents. Methods: One-hundred and eighty-six adolescent schizophrenia inpatients (88 males and 98 females) were involved in the study. Patients were treated with appropriate antipsychotic medication for 4 weeks. Weight, FBG, UA, triglyceride (TG), total cholesterol (TC), low-density lipoprotein (LDL), and high-density lipoprotein (HDL) were measured before and after treatment, and the levels were compared. Results: In female patients, compared with baseline, a significant increase in weight, TG, and LDL was observed after treatment (P<0.05), and no significant difference was observed in FBG, TC, UA, HDL, and the incidence of hypertriglyceridemia and hyperuricemia (P>0.05). In male patients, compared with baseline, a significant increase in weight, TG, LDL, UA, and the incidence of hypertriglyceridemia was observed after treatment (P<0.05), and no significant difference was observed in FBG, TC, HDL, and the incidence of hyperuricemia (P>0.05). The weight of 15 female patients (15.30%) and the weight of 14 male patients (15.91%) increased 7% compared with those before treatment. Conclusion: Atypical antipsychotic agents have a certain affection on lipid and uric acid metabolism in adolescent schizophrenia, especially in male patients．