To investigate the genetic association between Beta-2 Adrenergic Receptor (ADRB2) gene polymorphism and delayed cerebral vasospasm (DCVS) in patients with aneurysmal subarachnoid hemorrhage (aSAH) in the Han descent population in North of China. Methods: Two hundred and six aSAH patients were recruited. According to whether DCVS occurred, cases were divided into the DCVS group (n=128) and the non-DCVS group (n=78). Polymerase chain reaction-restriction fragment length polymorphism combined with DNA direct sequencing technique were used to determine the polymorphism of the ADRB2 gene. Results: Univariate analysis showed independent association between allele model (A vs. G) and the dominant model (A/A vs. A/G + G/G) of ADRB2 gene A46G polymorphism and DCVS. Multivariate Logistic regression analysis showed that ADRB2 gene +46 position allele G and genotype (A/G + G/G) were risk factors of DCVS for aSAH patients (OR=1.414, 95%CI: 1.142~4.817, P=0.039; OR=1.337, 95%CI: 1.076~3.191, P=0.045). However, there was no significant difference in the frequencies of genotype and allele of C79G polymorphism between the DCVS group and the non-DCVS group. Conclusion: For aSAH patients in the Han descent population in the North of China, A46G polymorphism ofADRB2 gene may closely related to DCVS.