Research Advances on the Role of Branched-Chain Amino Acid Metabolism in the Pathogenesis of Neurodegenerative Diseases

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Neural Injury and Functional Reconstruction ›› 0 DOI: 10.16780/j.cnki.sjssgncj.20251487

WANG Yidan ¹ , SHI Ling ¹ , JI Keaxiu ¹ , LIANG Xingqiu ² ,QIN Guihong ³ , ZHONG Jing ² , LIANG Mingkun ²

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Branched-chain amino acids (BCAAs), as essential amino acids, are closely associated with the onset

and progression of neurodegenerative diseases (NDDs). Recent studies have revealed that abnormal BCAAs

metabolism is intricately linked to the occurrence, progression, and prognosis of NDDs. This review summarizes

the metabolic characteristics of BCAAs in NDDs and the mechanisms by which they participate in the onset and

development of NDDs through regulating signaling pathways, ameliorating mitochondrial dysfunction,

alleviating neuroinflammation, and modulating epigenetics. It is hoped that this will provide further insights into

the specific mechanisms of BCAAs in NDDs and offer more evidence for precise clinical treatment of NDDs.

/ branched-chain amino acids / mTOR signaling pathway /

/ neuroinflammation

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WANG Yidan 1 , SHI Ling 1 , JI Keaxiu 1 , LIANG Xingqiu 2 , QIN Guihong 3 , ZHONG Jing 2 , LIANG Mingkun 2.

Research Advances on the Role of Branched-Chain Amino Acid Metabolism in the Pathogenesis of Neurodegenerative Diseases

[J]. Neural Injury and Functional Reconstruction. 0 https://doi.org/10.16780/j.cnki.sjssgncj.20251487

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