To preliminarily verify the efficacy and safety of using modular motion pattern rehabilitation robots for rehabilitation training in patients with spinal cord injury. Methods: A total of 100 inpatients with spinal cord injury were enrolled and divided into a control group and an experimental group, with 50 cases in each group, taking into account the spinal cord injury segment, severity, and personal willingness. All patients received conventional treatment. On this basis, the control group underwent conventional motor therapy training conducted by professional rehabilitation therapists for 60 minutes daily, while the experimental group received rehabilitation robot training for 60 minutes daily, both for a total of 6 weeks. Before and after treatment, the International Standards for Neurological Classification of Spinal Cord Injury (ISNCSCI), Modified Barthel Index (MBI), Spinal Cord Independence Measure version III (SCIM- Ⅲ), patient vital signs (blood pressure, pulse, and respiration), and adverse event records were used to evaluate efficacy and safety. Results: After treatment, motor scores, MBI scores, and SCIM-Ⅲ scores significantly improved in both groups (P<0.001). The experimental group showed significant improvements in light touch and pinprick sensation scores (P<0.05), while the control group showed no improvement (P>0.05). After treatment, the SCIM- Ⅲ score in the experimental group was superior to that in the control group (P<0.05), with no statistically significant differences in other indicators between the two groups (P>0.05). Conclusion: Both modular motion pattern rehabilitation robots and conventional motor therapy training contribute to improving motor function, enhancing activities of daily living, and increasing independence in patients with spinal cord injury. However, modular motion pattern rehabilitation robots demonstrate superior efficacy in improving patient independence and sensory function and are safe and effective in assisting with rehabilitation training and positional changes for patients with high-level spinal cord injuries.