To translate the English version of the Patient-Specific Functional Scale (PSFS) into Chinese and conduct cultural adaptation, then evaluate its reliability and validity among patients with ischemic stroke. Methods: The PSFS was translated into Chinese using Lee’s translation model, followed by cultural adaptation through expert consultation. A convenience sample of 120 patients hospitalized for ischemic stroke in the neurology department of a tertiary hospital in Xiangyang City from February to April 2024 was recruited to assess the reliability and validity of the Chinese version of the PSFS. Results: The content validity index of the Chinese version of the PSFS was 0.83. The internal consistency, measured by Cronbach’s α coefficient, was 0.777, and the intraclass correlation coefficient was 0.977. Conclusion: The Chinese version of the PSFS demonstrates good reliability and validity, making it a suitable tool for evaluating rehabilitation outcomes in patients with ischemic stroke under the Chinese context. It can provide a basis for formulating individualized rehabilitation training programs and assessing their effectiveness.