To evaluate the improvement effect of cognitive-motor dual-task training (CMDT) on cognitive function in post-stroke patients via Meta-analysis. Methods: Domestic and international databases including CNKI, Wanfang, VIP, SinoMed, PubMed, Web of Science (from database establishment to October 2024) were electronically searched to collect randomized controlled trials (RCTs) of CMDT for post-stroke cognitive impairment. RevMan 5.4.1 was used for Meta-analysis. Primary outcome measures included Mini-Mental State Examination (MMSE), Montreal Cognitive Assessment (MoCA), Trail Making Test A (TMT-A); the secondary outcome measure was modified Barthel Index (MBI), to assess the cognitive function improvement of stroke patients after CMDT intervention. Results: A total of 12 literatures (10 in Chinese, 2 in English) were included, with a total sample size of 1032 cases. Meta-analysis showed that the scores of MMSE and MoCA in the experimental group were significantly increased after treatment (WMD=2.55, 95%CI 1.35～ 3.75, P<0.01) (WMD=3.28, 95%CI 2.25～4.32, P<0.01). The TMT-A score was significantly decreased (WMD= － 9.95, 95% CI － 12.35 ～ － 7.55, P<0.05). The MBI score in the experimental group was significantly increased (WMD=12.58, 95% CI 10.31～14.86, P<0.01). Conclusion: CMDT can effectively improve the cognitive function of post-stroke patients.