Research Progress on the Pathogenesis of Chronic Fatigue Syndrome Based onMitochondrial Homeostasis

ZHU Minghang1
，YUAN Zhiying1
，FENG Chuwen2; 3
，QU Yuanyuan2
，LIU Tingting1
，LU Jing1
，SHAO Yuying2
，LI Binbin2
，GUO Shuhao1
，CHEN Tao1
，YANG Tiansong2; 3

doi:10.16780/j.cnki.sjssgncj.20241205

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Neural Injury and Functional Reconstruction ›› 2026, Vol. 21 ›› Issue (5) : 278-281. DOI: 10.16780/j.cnki.sjssgncj.20241205

Research Progress on the Pathogenesis of Chronic Fatigue Syndrome Based onMitochondrial Homeostasis

ZHU Minghang¹ ，YUAN Zhiying¹ ，FENG Chuwen^2,3 ，QU Yuanyuan² ，LIU Tingting¹ ，LU Jing¹ ，SHAO Yuying² ，LI Binbin² ，GUO Shuhao¹ ，CHEN Tao¹ ，YANG Tiansong^2,3

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Abstract

Chronic fatigue syndrome (CFS) is closely related to the imbalance of mitochondrial homeostasis, and studies have shown that mitochondria in CFS patients or model animals have abnormalities in morphology and structure, metabolism and quality control, which are closely related to the occurrence and/or development of CFS. In this paper, we take mitochondrial homeostasis as an entry point to systematically sort out its influence and role in the pathogenesis of CFS, with a view to providing more ideas and strategies for the study of potential mechanisms and treatment of chronic fatigue syndrome.

Key words

chronic fatigue syndrome; mitochondria; homeostasis

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ZHU Minghang¹ ，YUAN Zhiying¹ ，FENG Chuwen^2,3 ，QU Yuanyuan² ，LIU Tingting¹ ，LU Jing¹ ，SHAO Yuying² ，LI Binbin² ，GUO Shuhao¹ ，CHEN Tao¹ ，YANG Tiansong^2,3. Research Progress on the Pathogenesis of Chronic Fatigue Syndrome Based onMitochondrial Homeostasis[J]. Neural Injury and Functional Reconstruction. 2026, 21(5): 278-281 https://doi.org/10.16780/j.cnki.sjssgncj.20241205