To analyze the cerebral cortical oxygenation changes in stroke patients and healthy
controls during resting-state and task-state conditions using functional near-infrared spectroscopy (fNIRS)
technology. Methods: A total of 27 stroke patients (stroke group) and 15 healthy controls (healthy control
group) were included. Brain oxygenation changes during resting-state and the Verbal Fluency Task (VFT) were
collected using an fNIRS device. Results: Resting-state analysis revealed that the functional connectivity
strength across 26 channels involving multiple brain regions was higher in the stroke group compared to the
healthy control group, suggesting possible hyperactivation and compensatory mechanisms in the stroke group.
During the VFT task-state, the stroke group exhibited higher activation in the right dorsolateral prefrontal cortex
(DLPFC), right Broca's area, and left somatosensory cortex (SSC) compared to the healthy control group (P<
0.05). Significant differences in oxygen concentration were observed in the right DLPFC and right Broca's area
(P<0.05), while no significant difference was found in the left SSC. Conclusion: The cerebral functional
changes observed during resting-state and task-state conditions reflect disinhibition and compensatory
mechanisms in the brain following stroke, indicating that the stroke group may exhibit distinct neural adaptation
and reorganization phenomena in brain network function.
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