Stroke is characterized by high incidence, disability, mortality, recurrence, which poses a heavy burden on individuals and society. Acute ischemic stroke (AIS) is particularly common in clinical practice, and inflammatory response plays a crucial role in its pathological process. After the onset of AIS, neutrophils are the first activated peripheral immune cells to migrate to the ischemic parenchyma. These activated neutrophils exhibit a longer lifespan and trigger persistent inflammation that can lead to blood-brain barrier disruption, cerebral edema, and neurological deficits. Recent studies have found that intracranial neutrophils can undergo several manner of death: NETosis, apoptosis and pyroptosis. Neutrophils can be phagocytosed and cleared by macrophages/microglia. Moreover, they can also leave the local inflammatory tissue through reverse transendothelial migration. Thus, it is of great significance to elucidate the death and clearance mechanism of intracranial neutrophils for improving the prognosis of AIS.