As the principal afferent pathway for noxious stimuli, nociceptive sensory neurons have been shown to actively participate in tumor progression. Numerous studies indicate a complex bidirectional crosstalk between sensory neurons and tumors: tumors promote tumor innervation by releasing neurotrophic factors and axon guidance molecules, while sensory neurons remodel the tumor microenvironment by releasing neuropeptides, thereby modulating cancer proliferation, angiogenesis, immune evasion, and metastasis. However, this sensory neuro-tumor interaction exhibits marked heterogeneity across tumors of different organ origins, and its organ-specific mechanisms have yet to be systematically elucidated. Accordingly, this review aims to systematically delineate the organ-specific mechanisms by which nociceptive sensory neurons contribute to the initiation and progression of multiple solid tumors, evaluate the therapeutic potential of targeting the sensory neuron-tumor signaling axis, and provide a theoretical basis and research directions for developing organ-specific neuromodulatory strategies.