To compare different clinical features and laboratory data of infection of different variants of SARS-CoV-2, especially the impact on the sense of smell and taste. Methods: Forty-three hospitalized COVID-19 patients caused by Omicron variant (Omicron group) in Wuhan was enrolled. A previous published cohort of hospitalized COVID-19 patients (original group) during the first pandemic in Wuhan were age, sex, and disease severity-matched to the Omicron group in a ratio of 1∶1. The clinical features and laboratory data were compared between groups. Results: Patients in Omicron group were more likely to be comorbid with diabetes, malignancy and smoking history compared to original group. More patients in Omicron group complained fatigue, short of breath, cough, nasal obstruction and rhinorrhea. No significant difference in the incidence of olfactory dysfunction or gustatory dysfunction was found between groups. The serum IL-6 and IL-8 were lower in patients with gustatory dysfunction compared to those without gustatory dysfunction. Conclusion: Hospitalized COVID-19 patients caused by Omicron variant are with more comorbidities. The incidence of chemosensory dysfunction was similar in the hospitalized patients caused by Omicron and original strain.