To evaluate the impairment of motor and cognitive functions in patients with cerebellar infarction, analyze the differences in cognitive and motor functions between different infarct locations, and explore the correlation between motor and cognitive functions in this population. Methods: Thirty patients with focal cerebellar infarction admitted to the Department of Neurology at Beijing Tiantan Hospital were recruited as the case group, and 30 healthy subjects matched for age and education level with the case group were recruited as the control group. General information was collected from all subjects; the Addenbrooke’s Cognitive Examination-III (ACE-III) was used to assess cognitive function, the International Cooperative Ataxia Rating Scale (ICARS) was used to assess the degree of cerebellar ataxia, the Brunel Balance Assessment (BBA) was used to assess balance function, and the Finger Tapping Test (FTT) was used to assess fine motor function; comparisons were made between different groups, different infarct lobes, and different infarct sides. Results: The total ACE-III score, attention, and language fluency scores of the case group were lower than those of the control group (P<0.01 or P<0.05); patients with posterior lobe infarction had lower total ACE-III scores and attention scores than those with anterior lobe infarction (P<0.01 or P<0.05); patients with right cerebellar hemisphere infarction had lower total ACE-III scores, attention, and language fluency scores than those with left cerebellar hemisphere infarction (P<0.01 or P<0.05). The ICARS score of patients with cerebellar infarction was (12.4± 1.7), the BBA score was (10.9±1.4); regardless of side, the FTT of the case group was lower than that of the control group (P<0.01); patients with anterior lobe cerebellar infarction had higher ICARS scores than those with posterior lobe cerebellar infarction (P<0.01), lower BBA scores (P<0.01), and no significant difference in FTT scores; there were no statistically significant differences in ICARS, BBA, and FTT scores between patients with left and right cerebellar hemisphere infarctions. Correlation analysis did not find a correlation between motor and cognitive functions in patients with cerebellar infarction. Conclusion: There are differences in functional deficit symptoms among patients with cerebellar infarction at different lesion locations: patients with anterior cerebellar lobe damage have more severe motor disorders; patients with posterior cerebellar lobe and right cerebellar hemisphere damage have more severe cognitive impairments.