Stroke is the leading cause of death among residents in China, with approximately 30% of patients experiencing post-stroke depression (PSD). The severity and type of the stroke, as well as the volume, location, and lateralization of the cerebral lesion, living environment of patients, neurotransmitters, neuroinflammation, neuroendocrine dysfunction, and mitochondrial dysfunction are all implicated in the onset and progression of PSD. Non-pharmacological treatments represent a significant category within the primary treatment methods for PSD. This review summarizes the research progress on conventional non-pharmacological methods such as psychotherapy, non-invasive brain stimulation, electroacupuncture, and deep brain stimulation; it particularly highlights the progress in brain-computer interface technology and discusses its potential therapeutic value and future directions in the management of PSD. Investigating the pathophysiological mechanisms of PSD and developing innovative treatment strategies are of paramount clinical importance for enhancing patient outcomes.