Abstract
An ideal animal model of post-stroke dysphagia (PSD) can aid in deeply understanding its
physiological and pathological processes, thus promoting the development of research on this disease. Different
types of models exhibit diversity, allowing researchers to choose the appropriate animal model based on their
research content and practical needs. Currently, common methods for creating animal models of PSD include
photochemical induction, thread embolism, bilateral common carotid artery ligation, and type Ⅶ
collagenase-induced right hemorrhage plus right hypoglossal nerve injury. This article provides an overview and
comparison of the advantages and disadvantages of the above animal models in terms of experimental animal
selection, theoretical basis, modeling methods, and model characteristics. Compared with the other three
methods, the photochemical method has the characteristics of high survival rate and precise damage at specific
sites, and it holds certain advantages in evaluating brain plasticity at the cellular and molecular levels.
Key words
stroke
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Research Progress on Animal Models of Post-stroke Dysphagia[J]. Neural Injury and Functional Reconstruction. 2024, 19(12): 766-769
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