Research Progress on Animal Models of Post-stroke Dysphagia

Neural Injury and Functional Reconstruction ›› 2024, Vol. 19 ›› Issue (12) : 766-769.

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Neural Injury and Functional Reconstruction ›› 2024, Vol. 19 ›› Issue (12) : 766-769.
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Research Progress on Animal Models of Post-stroke Dysphagia

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Abstract

An ideal animal model of post-stroke dysphagia (PSD) can aid in deeply understanding its physiological and pathological processes, thus promoting the development of research on this disease. Different types of models exhibit diversity, allowing researchers to choose the appropriate animal model based on their research content and practical needs. Currently, common methods for creating animal models of PSD include photochemical induction, thread embolism, bilateral common carotid artery ligation, and type Ⅶ collagenase-induced right hemorrhage plus right hypoglossal nerve injury. This article provides an overview and comparison of the advantages and disadvantages of the above animal models in terms of experimental animal selection, theoretical basis, modeling methods, and model characteristics. Compared with the other three methods, the photochemical method has the characteristics of high survival rate and precise damage at specific sites, and it holds certain advantages in evaluating brain plasticity at the cellular and molecular levels.

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Research Progress on Animal Models of Post-stroke Dysphagia[J]. Neural Injury and Functional Reconstruction. 2024, 19(12): 766-769
PDF(5172 KB)

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