To analyze the impact of lifestyle factors on frailty in middle-aged and older adults, providing a theoretical basis for the management of frailty in this population. Methods: Data from 6945 individuals aged ≥45 years were extracted from the China Health and Retirement Longitudinal Study (CHARLS) database. Frailty levels were assessed using the frailty index (FI). Social demographic information, lifestyle, and health status of the participants were also collected. The influence of lifestyle on frailty in middle-aged and older adults was statistically analyzed. Results: After adjusting for gender, age, education level, and marital status through binary logistic regression analysis, it was found that middle-aged and older adults with the highest frequency of alcohol consumption >2 times/day (OR=1.85, 95% CI 1.00-3.39, P<0.047), nap duration >30 minutes (OR=1.57, 95% CI 1.22-2.02, P<0.001), and self-reported health status below“good”(OR=1.53, 95% CI 1.25-1.85, P<0.001) had a higher risk of frailty; those with high-intensity physical activity (OR=0.69, 95% CI 0.55-0.84, P<0.001), alcohol consumption frequency ≤1 time/day (OR=0.79, 95% CI 0.65-0.96, P=0.018), and nighttime sleep duration ≥6 hours (OR=0.71, 95% CI 0.62-0.81, P<0.001) had a lower risk of frailty. Conclu? sion: Lifestyle factors such as alcohol consumption, sleep, and physical activity may be associated with frailty status; a healthy lifestyle may help reduce the incidence of frailty in middle-aged and older adults.