To explore whether there is a causal relation between serum uric acid (SUA) levels and cerebral small vessel disease(CSVD). Methods: Data of SUA, lacunar infarction (LI), white matter hyperintensitie (WMH), fractional anisotropy (FA) and mean diffusivity (MD) were obtained from published genome-wide association study. Single nucleotide polymorphisms (SNPs) strongly associated with SUA (F-statistic>10) were selected as instrumental variables, and causal analysis is carried out by inverse variance weighted, MR-Egger, and Weighted median method. Meanwhile, the heterogeneity and horizontal pleiotropic tests were performed using MR-Egger intercept test and Cochran's Q test. Results: Inverse variance weighted showed that SUA was not associated with LI (OR=1.086, 95%CI 0.959～1.230, P=0.193), WMH (OR=1.010, 95%CI 0.956～1.066, P=0.725), FA (OR=1.058, 95%CI 0.848～1.320, P=0.617) and MD (OR=1.009, 95%CI 0.790～1.288, P=0.943). Moreover, sensitivity analysis showed no heterogeneity and horizontal pleiotropy. Conclusion: Current MR Studies had shown no causal relationship between SUA and CSVD, but standardized, large-sample clinical studies and large-scale GWAS-based MR Studies are needed to more fully evaluate the association.