Abstract
This study aims to explore the efficacy of a new repetitive transcranial magnetic
stimulation (rTMS) treatment protocol for primary trigeminal neuralgia (PTN). Methods: Sixty-four patients
with PTN were randomly divided into a control group and a treatment group, each consisting of 32 patients. The
control group received standard carbamazepine treatment, while the treatment group was given a progressive
decremental rTMS therapy (5 sessions per week for weeks 1-2; 2 sessions per week for weeks 3-4; 1 session per
week for weeks 5-8) in addition to carbamazepine treatment. Both groups underwent an 8-week treatment
period. The enrollment time point was designated as T0, and at the end of each week (T1-T8), assessments were
recorded. Visual Analogue Scale (VAS) and Brief Pain Inventory (BPI) were used to evaluate pain-related
indicators at T0-T8. Pittsburgh Sleep Quality Index (PSQI) was used to assess sleep quality at T0, T4, and T8, and
the BPI item assessing the impact of pain on daily life was used to evaluate quality of life. Results: Two
patients dropped out from each group, resulting in a final inclusion of 30 patients per group. There were no
statistically significant differences in VAS and BPI pain severity scores between the two groups at T0 and T1 (P>
0.05). From T2 to T8, the VAS and BPI pain severity scores decreased significantly more in the treatment group
compared to the control group (P<0.05). Before treatment, there were no statistically significant differences in
the scores of the impact of pain on daily life and PSQI between the two groups (P>0.05). At T4 and T8, the
treatment group showed a significantly greater reduction in the impact of pain on daily life and PSQI scores
compared to the control group (P<0.05). Conclusion: The rTMS treatment protocol adopted in this study can
effectively alleviate pain in PTN patients, reduce the impact of pain on daily living functions, and improve sleep
quality.
Key words
primary trigeminal neuralgia
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Observation of the Efficacy of a New Protocol for Repetitive Transcranial Magnetic
Stimulation in the Treatment of Primary Trigeminal Neuralgia[J]. Neural Injury and Functional Reconstruction. 2024, 19(10): 579-583
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