To systematically evaluate the efficacy of acupuncture combined with cognitive training in the treatment of post-stroke cognitive impairment. Methods: CNKI, VIP, WANFANG DATA, CBM, Pubmed, Web of Science Cochrane library, and other databases were searched for information on post-stroke cognitive impairment from October 2015 to May 2022; specifically, the search was to find the randomized controlled trials of acupuncture combined with cognitive training. The literature screening, data extraction, and research quality evaluation were conducted independently by two evaluators. The data were analyzed using RevMan5.4, and the mean difference (MD) and 95% confidence interval (CI) of the measurement data were calculated. Results: A total of 16 articles were included, comprising a total of 1 278 subjects. The results showed that acupuncture combined with cognitive rehabilitation training could improve the clinical efficacy of patients with cognitive impairment after stroke [RR=1.26, 95%CI (1.16, 1.36), P<0.00001], Montreal Cognitive Assessment scale score [MD=2.78, 95% CI (1.52, 4.04), P<0.00001], Mini Mental State Examination score [MD=3.80, 95% CI (1.84, 5.76), P=0.0001], and modified Barthel Index score [MD=10.17, 95%CI (5.69, 14.65), P<0.00001] were superior to those for the control group. The evidence quality of each outcome index was evaluated by GRADE rating. The treatment efficiency and FMA were intermediate, and the MMSE, MoCA, and MBI were low. Conclusion: Compared with routine treatment, acupuncture combined with cognitive training can significantly improve post-stroke cognitive impairmentTo systematically evaluate the efficacy of acupuncture combined with cognitive training in the treatment of post-stroke cognitive impairment. Methods: CNKI, VIP, WANFANG DATA, CBM, Pubmed, Web of Science Cochrane library, and other databases were searched for information on post-stroke cognitive impairment from October 2015 to May 2022; specifically, the search was to find the randomized controlled trials of acupuncture combined with cognitive training. The literature screening, data extraction, and research quality evaluation were conducted independently by two evaluators. The data were analyzed using RevMan5.4, and the mean difference (MD) and 95% confidence interval (CI) of the measurement data were calculated. Results: A total of 16 articles were included, comprising a total of 1 278 subjects. The results showed that acupuncture combined with cognitive rehabilitation training could improve the clinical efficacy of patients with cognitive impairment after stroke [RR=1.26, 95%CI (1.16, 1.36), P<0.00001], Montreal Cognitive Assessment scale score [MD=2.78, 95% CI (1.52, 4.04), P<0.00001], Mini Mental State Examination score [MD=3.80, 95% CI (1.84, 5.76), P=0.0001], and modified Barthel Index score [MD=10.17, 95%CI (5.69, 14.65), P<0.00001] were superior to those for the control group. The evidence quality of each outcome index was evaluated by GRADE rating. The treatment efficiency and FMA were intermediate, and the MMSE, MoCA, and MBI were low. Conclusion: Compared with routine treatment, acupuncture combined with cognitive training can significantly improve post-stroke cognitive impairment